Ontology highlight
ABSTRACT:
SUBMITTER: Scott MC
PROVIDER: S-EPMC4653667 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Scott Milcah C MC Sarver Aaron L AL Tomiyasu Hirotaka H Cornax Ingrid I Van Etten Jamie J Varshney Jyotika J O'Sullivan M Gerard MG Subramanian Subbaya S Modiano Jaime F JF
The Journal of biological chemistry 20150916 47
We previously identified two distinct molecular subtypes of osteosarcoma through gene expression profiling. These subtypes are associated with distinct tumor behavior and clinical outcomes. Here, we describe mechanisms that give rise to these molecular subtypes. Using bioinformatic analyses, we identified a significant association between deregulation of the retinoblastoma (RB)-E2F pathway and the molecular subtype with worse clinical outcomes. Xenotransplantation models recapitulated the corres ...[more]