Ontology highlight
ABSTRACT:
SUBMITTER: Kim SJ
PROVIDER: S-EPMC3646795 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Kim Sang Jin SJ Ko Jung Hwa JH Yun Ji-Hyun JH Kim Ju-A JA Kim Tae Eun TE Lee Hyun Ju HJ Kim Seok Hwan SH Park Ki Ho KH Oh Joo Youn JY
PloS one 20130507 5
Optic neuropathy including glaucoma is one of the leading causes of irreversible vision loss, and there are currently no effective therapies. The hallmark of pathophysiology of optic neuropathy is oxidative stress and apoptotic death of retinal ganglion cells (RGCs), a population of neurons in the central nervous system with their soma in the inner retina and axons in the optic nerve. We here tested that an anti-apoptotic protein stanniocalcin-1 (STC-1) can prevent loss of RGCs in the rat retina ...[more]