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Plasmon based biosensor for distinguishing different peptides mutation states.


ABSTRACT: Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild/mutated peptides. The results demonstrate the probing and the screening of wild/mutated BRCA1 peptides, thus opening a path for the fabrication of simple and cheap SERS device capable of early detection of several diseases.

SUBMITTER: Das G 

PROVIDER: S-EPMC3647166 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Plasmon based biosensor for distinguishing different peptides mutation states.

Das Gobind G   Chirumamilla Manohar M   Toma Andrea A   Gopalakrishnan Anisha A   Zaccaria Remo Proietti RP   Alabastri Alessandro A   Leoncini Marco M   Di Fabrizio Enzo E  

Scientific reports 20130101


Periodic and reproducible gold nanocuboids with various matrix dimensions and with different inter-particle gaps were fabricated by means of top-down technique. Rhodamine 6G was used as a probe molecule to optimize the design and the fabrication of the cuboid nanostructures. The electric field distribution for the nanocuboids with varying matrix dimensions/inter-particle gap was also investigated. These SERS devices were employed as biosensors through the investigation of both myoglobin and wild  ...[more]

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