Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3647168 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhang Liangyu L Shao Hengyi H Zhu Tongge T Xia Peng P Wang Zhikai Z Liu Lifang L Yan Maomao M Hill Donald L DL Fang Guowei G Chen Zhengjun Z Wang Dongmei D Yao Xuebiao X
Scientific reports 20130101
Cell motility and adhesion involve orchestrated interaction of microtubules (MTs) with their plus-end tracking proteins (+TIPs). However, the mechanisms underlying regulations of MT dynamics and directional cell migration are still elusive. Here, we show that DDA3-EB1 interaction orchestrates MT plus-end dynamics and facilitates directional cell migration. Biochemical characterizations reveal that DDA3 interacts with EB1 via its SxIP motif within the C-terminal Pro/Ser-rich region. Time-lapse an ...[more]