Ontology highlight
ABSTRACT:
SUBMITTER: Ohashi K
PROVIDER: S-EPMC3647768 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Ohashi Kazuto K Kawai Shigeyuki S Murata Kousaku K
Eukaryotic cell 20130301 5
NAD(+) is synthesized from tryptophan either via the kynurenine (de novo) pathway or via the salvage pathway by reutilizing intermediates such as nicotinic acid or nicotinamide ribose. Quinolinic acid is an intermediate in the kynurenine pathway. We have discovered that the budding yeast Saccharomyces cerevisiae secretes quinolinic acid into the medium and also utilizes extracellular quinolinic acid as a novel NAD(+) precursor. We provide evidence that extracellular quinolinic acid enters the ce ...[more]