Ontology highlight
ABSTRACT:
SUBMITTER: Caron S
PROVIDER: S-EPMC3648076 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Caron Sandrine S Huaman Samanez Carolina C Dehondt Hélène H Ploton Maheul M Briand Olivier O Lien Fleur F Dorchies Emilie E Dumont Julie J Postic Catherine C Cariou Bertrand B Lefebvre Philippe P Staels Bart B
Molecular and cellular biology 20130325 11
The glucose-activated transcription factor carbohydrate response element binding protein (ChREBP) induces the expression of hepatic glycolytic and lipogenic genes. The farnesoid X receptor (FXR) is a nuclear bile acid receptor controlling bile acid, lipid, and glucose homeostasis. FXR negatively regulates hepatic glycolysis and lipogenesis in mouse liver. The aim of this study was to determine whether FXR regulates the transcriptional activity of ChREBP in human hepatocytes and to unravel the un ...[more]