Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC3648105 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Wang Shanshan S Zhao Zhendong Z Bi Yuhai Y Sun Lei L Liu Xiaoling X Liu Wenjun W
Journal of virology 20130327 11
Phosphorylation of viral proteins plays important roles in the influenza A virus (IAV) life cycle. By using mass spectrometry, we identified tyrosine 132 (Y132) as a phosphorylation site of the matrix protein (M1) of the influenza virus A/WSN/1933(H1N1). Phosphorylation at this site is essential to the process of virus replication by controlling the nuclear import of M1. We further demonstrated that the phosphorylated tyrosine is crucial for the binding of M1 to the nuclear import factor importi ...[more]