Ontology highlight
ABSTRACT:
SUBMITTER: Betous R
PROVIDER: S-EPMC3650004 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Bétous Rémy R Glick Gloria G GG Zhao Runxiang R Cortez David D
PloS one 20130509 5
SMARCAL1 is an ATPase in the SNF2 family that functions at damaged replication forks to promote their stability and restart. It acts by translocating on DNA to catalyze DNA strand annealing, branch migration, and fork regression. Many SNF2 enzymes work as motor subunits of large protein complexes. To determine if SMARCAL1 is also a member of a protein complex and to further understand how it functions in the replication stress response, we used a proteomics approach to identify interacting prote ...[more]