SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes.

ABSTRACT:

Background

Small ubiquitin-like modifiers (SUMO) are covalently conjugated to other proteins including nuclear receptors leading to modification of various cellular processes.

Results

Ligand-dependent SUMOylation of farnesoid X receptor (FXR) negatively regulates the expression of its target genes.

Conclusion

SUMO modification attenuates the capacity of FXR to function as a transcriptional activator.

Significance

Defining post-translation modification of FXR bySUMOis important to understanding how this nuclear receptor functions in health and disease. The farnesoid X receptor (FXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metabolism including bile acid homeostasis. Here we show that FXR is covalently modified b

SUBMITTER: Balasubramaniyan N 

PROVIDER: S-EPMC3650421 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature