Ontology highlight
ABSTRACT:
SUBMITTER: Wong LH
PROVIDER: S-EPMC3650558 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Wong Lai Hong LH Unciti-Broceta Asier A Spitzer Michaela M White Rachel R Tyers Mike M Harrington Lea L
Chemistry & biology 20130301 3
Telomerase comprises a reverse transcriptase and an internal RNA template that maintains telomeres in many eukaryotes, and it is a well-validated cancer target. However, there is a dearth of small molecules with efficacy against human telomerase in vivo. We developed a surrogate yeast high-throughput assay to identify human telomerase inhibitors. The reversibility of growth arrest induced by active human telomerase was assessed against a library of 678 compounds preselected for bioactivity in S. ...[more]