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Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia.

ABSTRACT: Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant for psychiatric disorders.

SUBMITTER: Bloom RJ

PROVIDER: S-EPMC3650833 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia.

Bloom Rachael J RJ Kähler Anna K AK Collins Ann L AL Chen Guanhua G Cannon Tyrone D TD Hultman Christina C Sullivan Patrick F PF

Schizophrenia research 20130316 1-3

Copy number variation plays a clear role in the etiology of many psychiatric disorders, particularly schizophrenia. We performed array-CGH to look for copy number variants between five pairs of monozygotic twins discordant for bipolar disorder or schizophrenia. Our study found no differences in copy number variants between the sets of twins. Although alluring, realistic accounting for heterogeneity and chimerism highlights the technological limitations in studying monozygotic twins discordant fo ...[more]

PMID: 23507357

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Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder.

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Phenotypically concordant and discordant monozygotic twins display different DNA copy number variation profiles

Project description:This SuperSeries is composed of the SubSeries listed below.

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