Interleukin-13 signaling and its role in asthma.
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ABSTRACT:
SUBMITTER: Rael EL
PROVIDER: S-EPMC3651056 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Interleukin-13 signaling and its role in asthma.
Rael Efren L EL Lockey Richard F RF
The World Allergy Organization journal 20110301 3
Asthma affects nearly 300 million people worldwide. The majority respond to inhaled corticosteroid treatment with or without beta-adrenergic agonists. However, a subset of 5 to 10% with severe asthma do not respond optimally to these medications. Different phenotypes of asthma may explain why current therapies show limited benefits in subgroups of patients. Interleukin-13 is implicated as a central regulator in IgE synthesis, mucus hypersecretion, airway hyperresponsiveness, and fibrosis. Promis ...[more]
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