Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for people with asthma.
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ABSTRACT:
SUBMITTER: Gallagher A
PROVIDER: S-EPMC8524317 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for people with asthma.
Gallagher Andrew A Edwards Michaela M Nair Parameswaran P Drew Stewart S Vyas Aashish A Sharma Rashmi R Marsden Paul A PA Wang Ran R Evans David Jw DJ
The Cochrane database of systematic reviews 20211019
<h4>Background</h4>Targeting the immunoglobulin E pathway and the interleukin-5 pathway with specific monoclonal antibodies directed against the cytokines or their receptors is effective in patients with severe asthma. However, there are patients who have suboptimal responses to these biologics. Since interleukin-4 and interleukin-13, signalling through the interleukin-4 receptor, have multiple effects on the biology of asthma, therapies targeting interleukin-4 and -13 (both individually and com ...[more]
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