Ontology highlight
ABSTRACT:
SUBMITTER: Hedskog L
PROVIDER: S-EPMC3651455 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Hedskog Louise L Pinho Catarina Moreira CM Filadi Riccardo R Rönnbäck Annica A Hertwig Laura L Wiehager Birgitta B Larssen Pia P Gellhaar Sandra S Sandebring Anna A Westerlund Marie M Graff Caroline C Winblad Bengt B Galter Dagmar D Behbahani Homira H Pizzo Paola P Glaser Elzbieta E Ankarcrona Maria M
Proceedings of the National Academy of Sciences of the United States of America 20130425 19
It is well-established that subcompartments of endoplasmic reticulum (ER) are in physical contact with the mitochondria. These lipid raft-like regions of ER are referred to as mitochondria-associated ER membranes (MAMs), and they play an important role in, for example, lipid synthesis, calcium homeostasis, and apoptotic signaling. Perturbation of MAM function has previously been suggested in Alzheimer's disease (AD) as shown in fibroblasts from AD patients and a neuroblastoma cell line containin ...[more]