Ontology highlight
ABSTRACT:
SUBMITTER: Koczian F
PROVIDER: S-EPMC6395311 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Koczian Fabian F Nagło Olga O Vomacka Jan J Vick Binje B Servatius Phil P Zisis Themistoklis T Hettich Britta B Kazmaier Uli U Sieber Stephan A SA Jeremias Irmela I Zahler Stefan S Braig Simone S
Haematologica 20181011 3
Combination chemotherapy has proven to be a favorable strategy to treat acute leukemia. However, the introduction of novel compounds remains challenging and is hindered by a lack of understanding of their mechanistic interactions with established drugs. In the present study, we demonstrate a highly increased response of various acute leukemia cell lines, drug-resistant cells and patient-derived xenograft cells by combining the recently introduced protein disulfide isomerase inhibitor PS89 with c ...[more]