Ontology highlight
ABSTRACT:
SUBMITTER: Richard VR
PROVIDER: S-EPMC3651518 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Richard Vincent R VR Leonov Anna A Beach Adam A Burstein Michelle T MT Koupaki Olivia O Gomez-Perez Alejandra A Levy Sean S Pluska Lukas L Mattie Sevan S Rafesh Rami R Iouk Tatiana T Sheibani Sara S Greenwood Michael M Vali Hojatollah H Titorenko Vladimir I VI
Aging 20130401 4
Macromitophagy controls mitochondrial quality and quantity. It involves the sequestration of dysfunctional or excessive mitochondria within double-membrane autophagosomes, which then fuse with the vacuole/lysosome to deliver these mitochondria for degradation. To investigate a physiological role of macromitophagy in yeast, we examined how theatg32Δ-dependent mutational block of this process influences the chronological lifespan of cells grown in a nutrient-rich medium containing low (0.2%) conce ...[more]