Ontology highlight
ABSTRACT:
SUBMITTER: Princz A
PROVIDER: S-EPMC7511317 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Princz Andrea A Pelisch Federico F Tavernarakis Nektarios N
Scientific reports 20200923 1
The insulin/IGF signalling pathway impacts lifespan across distant taxa, by controlling the activity of nodal transcription factors. In the nematode Caenorhabditis elegans, the transcription regulators DAF-16/FOXO and SKN-1/Nrf function to promote longevity under conditions of low insulin/IGF signalling and stress. The activity and subcellular localization of both DAF-16 and SKN-1 is further modulated by specific posttranslational modifications, such as phosphorylation and ubiquitination. Here, ...[more]