Ontology highlight
ABSTRACT:
SUBMITTER: Broderick JP
PROVIDER: S-EPMC3651875 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Broderick Joseph P JP Palesch Yuko Y YY Demchuk Andrew M AM Yeatts Sharon D SD Khatri Pooja P Hill Michael D MD Jauch Edward C EC Jovin Tudor G TG Yan Bernard B Silver Frank L FL von Kummer Rüdiger R Molina Carlos A CA Demaerschalk Bart M BM Budzik Ronald R Clark Wayne M WM Zaidat Osama O OO Malisch Tim W TW Goyal Mayank M Schonewille Wouter J WJ Mazighi Mikael M Engelter Stefan T ST Anderson Craig C Spilker Judith J Carrozzella Janice J Ryckborst Karla J KJ Janis L Scott LS Martin Renée H RH Foster Lydia D LD Tomsick Thomas A TA
The New England journal of medicine 20130207 10
<h4>Background</h4>Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a combined approach is more effective than intravenous t-PA alone is uncertain.<h4>Methods</h4>We randomly assigned eligible patients who had received intravenous t-PA within 3 hours after symptom onset to receive additional endovascular therapy or intravenous t-PA alone, in a 2:1 ratio. Th ...[more]