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Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.

ABSTRACT: Cell polarity plays an important role in tissue morphogenesis; however, the mechanisms of polarity and their role in mammalian development are still poorly understood. We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper branching morphogenesis and progenitor differentiation in mammalian lung. We found that during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for the apical maintenance of atypical protein kinase C (aPKC). These results identify Dlg5 as a regulator of apical polarity complexes and uncover the critical function of Dlg5 in branching morphogenesis and differentiation of lung progenitor cells.

SUBMITTER: Nechiporuk T

PROVIDER: S-EPMC3652546 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.

Nechiporuk Tamilla T Klezovitch Olga O Nguyen Liem L Vasioukhin Valeri V

Developmental biology 20130304 2

Cell polarity plays an important role in tissue morphogenesis; however, the mechanisms of polarity and their role in mammalian development are still poorly understood. We show here that membrane-associated guanylate kinase protein Dlg5 is required for proper branching morphogenesis and progenitor differentiation in mammalian lung. We found that during lung development Dlg5 functions as an apical-basal polarity protein, which is necessary for the apical maintenance of atypical protein kinase C (a ...[more]

PMID: 23466739

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