An MRI-histological study of white matter in stroke-free SHRSP.
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ABSTRACT:
SUBMITTER: Brittain JF
PROVIDER: S-EPMC3652693 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
An MRI-histological study of white matter in stroke-free SHRSP.
Brittain John F JF McCabe Christopher C Khatun Halima H Kaushal Nitika N Bridges Leslie R LR Holmes William M WM Barrick Thomas R TR Graham Delyth D Dominiczak Anna F AF Mhairi Macrae I I Hainsworth Atticus H AH
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20130213 5
Hypertension is associated with cerebral small vessel disease (SVD) and with diffuse white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging (MRI). We tested whether stroke-prone spontaneously hypertensive rats (SHRSP), a model of chronic hypertension, exhibit WMH. Male SHRSP (age 10 months) without stroke symptoms were compared with age-matched male WKY rats. Stroke-prone spontaneously hypertensive rats exhibited no WMH on MRI scans (T2, T2*, diffusion tensor imaging) and ...[more]
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