Targeted ANP32E mutant mice do not demonstrate obvious movement defects.
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ABSTRACT:
SUBMITTER: Wong P
PROVIDER: S-EPMC3652840 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Targeted ANP32E mutant mice do not demonstrate obvious movement defects.
Wong Peiyan P Leo Vonny I VI Low Meijun M Mak Tak W TW Zhang Xiaodong X Reilly Patrick T PT
PloS one 20130513 5
<h4>Background</h4>The ANP32 family of proteins have been implicated in neuronal function through biochemical and cellular biology studies in neurons, as well as by recent behavioural studies of a gene-trapped loss-of-function mutation of Anp32e in mice, particularly with respect to fine motor function. A second targeted allele of the Anp32e, however, did not appear to demonstrate neurological phenotypes.<h4>Methodology/principal findings</h4>Using a stringently controlled cohort of ten-generati ...[more]
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