Ontology highlight
ABSTRACT:
SUBMITTER: Corbin IR
PROVIDER: S-EPMC3652907 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Nanomedicine (London, England) 20121015 6
<h4>Aim</h4>The targeting efficiency of folate receptor-α (FR-α)-targeted high-density lipoprotein nanoparticles (HDL NPs) was evaluated in a syngeneic mouse model of ovarian cancer.<h4>Materials & methods</h4>Folic acid was conjugated to the surface of fluorescent-labeled HDL NPs. In vivo tumor targeting of folic acid-HDL NPs and HDL NPs were evaluated in mice with metastatic ovarian cancer following intravenous or intraperitoneal (ip.) administration.<h4>Results & discussion</h4>Intravenous FR ...[more]