Ontology highlight
ABSTRACT:
SUBMITTER: Teles RM
PROVIDER: S-EPMC3653587 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130228 6126
Type I interferons (IFN-α and IFN-β) are important for protection against many viral infections, whereas type II interferon (IFN-γ) is essential for host defense against some bacterial and parasitic pathogens. Study of IFN responses in human leprosy revealed an inverse correlation between IFN-β and IFN-γ gene expression programs. IFN-γ and its downstream vitamin D-dependent antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity a ...[more]