Kallikrein-Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation.
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ABSTRACT:
SUBMITTER: Seliga A
PROVIDER: S-EPMC5801412 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
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Kallikrein-Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation.
Seliga Alecia A Lee Michael Hweemoon MH Fernandes Nicole C NC Zuluaga-Ramirez Viviana V Didukh Marta M Persidsky Yuri Y Potula Raghava R Gallucci Stefania S Sriram Uma U
Frontiers in immunology 20180202
The Kallikrein-Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report, we show that KKS regulates Type I IFN responses, thought to be important in lupus pathogenesis. We used CpG (TLR9 ligand), R848 (TLR7 ligand), or recombinant IFN-α to induce interferon-stimulated genes (ISG ...[more]
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