Ontology highlight
ABSTRACT:
SUBMITTER: Paley MA
PROVIDER: S-EPMC3653769 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Paley Michael A MA Kroy Daniela C DC Odorizzi Pamela M PM Johnnidis Jonathan B JB Dolfi Douglas V DV Barnett Burton E BE Bikoff Elizabeth K EK Robertson Elizabeth J EJ Lauer Georg M GM Reiner Steven L SL Wherry E John EJ
Science (New York, N.Y.) 20121101 6111
Chronic infections strain the regenerative capacity of antiviral T lymphocyte populations, leading to failure in long-term immunity. The cellular and molecular events controlling this regenerative capacity, however, are unknown. We found that two distinct states of virus-specific CD8(+) T cells exist in chronically infected mice and humans. Differential expression of the T-box transcription factors T-bet and Eomesodermin (Eomes) facilitated the cooperative maintenance of the pool of antiviral CD ...[more]