Ontology highlight
ABSTRACT:
SUBMITTER: Liu N
PROVIDER: S-EPMC3653909 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Liu Nan N Wang Mengxi M Deng Wen W Schmidt Christine S CS Qin Weihua W Leonhardt Heinrich H Spada Fabio F
PloS one 20130514 5
Tet proteins are emerging as major epigenetic modulators of cell fate and plasticity. However, little is known about how Tet proteins are targeted to selected genomic loci in distinct biological contexts. Previously, a CXXC-type zinc finger domain in Tet1 was shown to bind CpG-rich DNA sequences. Interestingly, in human and mouse the Tet2 and Tet3 genes are adjacent to Cxxc4 and Cxxc10-1, respectively. The CXXC domains encoded by these loci, together with those in Tet1 and Cxxc5, identify a dist ...[more]