Ontology highlight
ABSTRACT:
SUBMITTER: Viphakone N
PROVIDER: S-EPMC3654228 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Viphakone Nicolas N Hautbergue Guillaume M GM Walsh Matthew M Chang Chung-Te CT Holland Arthur A Folco Eric G EG Reed Robin R Wilson Stuart A SA
Nature communications 20120101
The metazoan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA to the cytoplasm. Nxf1 is an mRNA export receptor, which binds processed mRNA and transports it through the nuclear pore complex. At present, the relationship between TREX and Nxf1 is not understood. Here we show that Nxf1 uses an intramolecular interaction to inhibit its own RNA-binding activity. When the TREX subunits Aly and Thoc5 make contact with Nxf1, Nxf1 is driven into an open con ...[more]