Ontology highlight
ABSTRACT:
SUBMITTER: Muller-McNicoll M
PROVIDER: S-EPMC4782049 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Müller-McNicoll Michaela M Botti Valentina V de Jesus Domingues Antonio M AM Brandl Holger H Schwich Oliver D OD Steiner Michaela C MC Curk Tomaz T Poser Ina I Zarnack Kathi K Neugebauer Karla M KM
Genes & development 20160301 5
Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. How and why cells use numerous different export adaptors is poorly understood. Here we critically evaluate members of the SR protein family (SRSF1-7) for their potential to act as NXF1 adaptors that couple pre-mRNA processing to mRNA export. Consistent with this proposal, >1000 endogenous mRNAs required individual SR proteins for nuclear export in vivo. To address the mechanism, t ...[more]