High-density lipoproteins delivering interleukin-15.
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ABSTRACT:
SUBMITTER: Ochoa MC
PROVIDER: S-EPMC3654572 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
High-density lipoproteins delivering interleukin-15.
Ochoa Maria C MC Melero Ignacio I Berraondo Pedro P
Oncoimmunology 20130401 4
Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved in IL-15 trans-presentation. ...[more]
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