Ontology highlight
ABSTRACT:
SUBMITTER: Robinson DR
PROVIDER: S-EPMC3654808 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Robinson Dan R DR Wu Yi-Mi YM Kalyana-Sundaram Shanker S Cao Xuhong X Lonigro Robert J RJ Sung Yun-Shao YS Chen Chun-Liang CL Zhang Lei L Wang Rui R Su Fengyun F Iyer Matthew K MK Roychowdhury Sameek S Siddiqui Javed J Pienta Kenneth J KJ Kunju Lakshmi P LP Talpaz Moshe M Mosquera Juan Miguel JM Singer Samuel S Schuetze Scott M SM Antonescu Cristina R CR Chinnaiyan Arul M AM
Nature genetics 20130113 2
A 44-year old woman with recurrent solitary fibrous tumor (SFT)/hemangiopericytoma was enrolled in a clinical sequencing program including whole-exome and transcriptome sequencing. A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 was detected. Transcriptome sequencing of 27 additional SFTs identified the presence of a NAB2-STAT6 gene fusion in all tumors. Using RT-PCR and sequencing, we detected this fusion in all 51 SFTs, indicating high levels of rec ...[more]