Ontology highlight
ABSTRACT:
SUBMITTER: Chmielecki J
PROVIDER: S-EPMC3984043 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Chmielecki Juliann J Crago Aimee M AM Rosenberg Mara M O'Connor Rachael R Walker Sarah R SR Ambrogio Lauren L Auclair Daniel D McKenna Aaron A Heinrich Michael C MC Frank David A DA Meyerson Matthew M
Nature genetics 20130113 2
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs. ...[more]