Ontology highlight
ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC3654841 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Zhao Wei W Marchani Elizabeth E EE Cheung Charles Y K CY Steinbart Ellen J EJ Schellenberg Gerard D GD Bird Thomas D TD Wijsman Ellen M EM
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20130125 2
Alzheimer's disease (AD) is a common, genetically complex, fatal neurodegenerative disorder of late life. Although several genes are known to play a role in early-onset AD, identification of the genetic basis of late onset AD (LOAD) has been challenging, with only the APOE gene known to have a high contribution to both AD risk and age-at-onset. Here, we present the first genome-scan analysis of the complete, well-characterized University of Washington LOAD sample of 119 pedigrees, using age-at-o ...[more]