Ontology highlight
ABSTRACT:
SUBMITTER: Grupe A
PROVIDER: S-EPMC1380225 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Grupe Andrew A Li Yonghong Y Rowland Charles C Nowotny Petra P Hinrichs Anthony L AL Smemo Scott S Kauwe John S K JS Maxwell Taylor J TJ Cherny Sara S Doil Lisa L Tacey Kristina K van Luchene Ryan R Myers Amanda A Wavrant-De Vrièze Fabienne F Kaleem Mona M Hollingworth Paul P Jehu Luke L Foy Catherine C Archer Nicola N Hamilton Gillian G Holmans Peter P Morris Chris M CM Catanese Joseph J Sninsky John J White Thomas J TJ Powell John J Hardy John J O'Donovan Michael M Lovestone Simon S Jones Lesley L Morris John C JC Thal Leon L Owen Michael M Williams Julie J Goate Alison A
American journal of human genetics 20051115 1
Strong evidence of linkage to late-onset Alzheimer disease (LOAD) has been observed on chromosome 10, which implicates a wide region and at least one disease-susceptibility locus. Although significant associations with several biological candidate genes on chromosome 10 have been reported, these findings have not been consistently replicated, and they remain controversial. We performed a chromosome 10-specific association study with 1,412 gene-based single-nucleotide polymorphisms (SNPs), to ide ...[more]