Ontology highlight
ABSTRACT:
SUBMITTER: Lin AY
PROVIDER: S-EPMC3655178 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lin Adam Yuh AY Almeida Joao Paulo Mattos JP Bear Adham A Liu Nathan N Luo Laureen L Foster Aaron Edward AE Drezek Rebekah Anna RA
PloS one 20130515 5
Gold nanoparticle accumulation in immune cells has commonly been viewed as a side effect for cancer therapeutic delivery; however, this phenomenon can be utilized for developing gold nanoparticle mediated immunotherapy. Here, we conjugated a modified CpG oligodeoxynucleotide immune stimulant to gold nanoparticles using a simple and scalable self-assembled monolayer scheme that enhanced the functionality of CpG in vitro and in vivo. Nanoparticles can attenuate systemic side effects by enhancing C ...[more]