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Enhanced nanoparticle delivery exploiting tumour-responsive formulations.

ABSTRACT: Nanoparticles can be used as drug carriers, contrast agents and radiosensitisers for the treatment of cancer. Nanoparticles can either passively accumulate within tumour sites, or be conjugated with targeting ligands to actively enable tumour deposition. With respect to passive accumulation, particles?

SUBMITTER: Bennie LA

PROVIDER: S-EPMC6276285 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Enhanced nanoparticle delivery exploiting tumour-responsive formulations.

Bennie Lindsey A LA McCarthy Helen O HO Coulter Jonathan A JA

Cancer nanotechnology 20181121 1

Nanoparticles can be used as drug carriers, contrast agents and radiosensitisers for the treatment of cancer. Nanoparticles can either passively accumulate within tumour sites, or be conjugated with targeting ligands to actively enable tumour deposition. With respect to passive accumulation, particles < 150 nm accumulate with higher efficiency within the tumour microenvironment, a consequence of the enhanced permeability and retention effect. Despite these favourable properties, clinical transla ...[more]

PMID: 30595759

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