Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study.
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ABSTRACT: Background
Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung function in CF.Methods
Cross-sectional study design using UK CF registry data from 2096 clinically stable adults.Results
Serum creatinine and BMI were positively and independently associated with FEV1 and FVC. One standard deviation increment in serum creatinine was associated with an FEV1 increase of 171ml (95% confidence intervals CI: +116 to +227ml) in males and 90ml (95% CI: +46 to +133ml) in females. Compared to the reference group of 20-24.9kg/m(2), those with a BMI<20kg/m(2) had lower FEV1 with values of -642ml (95%CI: -784 to -500ml) for males and -468ml (95%CI: -564 to -372ml) for females.Conclusions
Prospective studies and controlled trials are required to ascertain if these associations have therapeutic potential in modifying disease progression.
SUBMITTER: Forrester DL
PROVIDER: S-EPMC3655260 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Measures of body habitus are associated with lung function in adults with cystic fibrosis: a population-based study.
Forrester Doug L DL Knox Alan J AJ Smyth Alan R AR Fogarty Andrew W AW
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20120905 3
<h4>Background</h4>Body habitus differences may explain some of the variation in lung function between individuals with cystic fibrosis (CF). We tested the hypothesis that measures of lean muscle mass and obesity are independently associated with lung function in CF.<h4>Methods</h4>Cross-sectional study design using UK CF registry data from 2096 clinically stable adults.<h4>Results</h4>Serum creatinine and BMI were positively and independently associated with FEV1 and FVC. One standard deviation ...[more]
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