Ontology highlight
ABSTRACT:
SUBMITTER: Kenzelmann Broz D
PROVIDER: S-EPMC3656320 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Kenzelmann Broz Daniela D Spano Mello Stephano S Bieging Kathryn T KT Jiang Dadi D Dusek Rachel L RL Brady Colleen A CA Sidow Arend A Attardi Laura D LD
Genes & development 20130501 9
The mechanisms by which the p53 tumor suppressor acts remain incompletely understood. To gain new insights into p53 biology, we used high-throughput sequencing to analyze global p53 transcriptional networks in primary mouse embryo fibroblasts in response to DNA damage. Chromatin immunoprecipitation sequencing reveals 4785 p53-bound sites in the genome located near 3193 genes involved in diverse biological processes. RNA sequencing analysis shows that only a subset of p53-bound genes is transcrip ...[more]