Ontology highlight
ABSTRACT:
SUBMITTER: Belinsky MG
PROVIDER: S-EPMC3656383 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Belinsky Martin G MG Rink Lori L von Mehren Margaret M
Frontiers in oncology 20130517
Gastrointestinal stromal tumors (GISTs) in adults are generally driven by somatic gain-of-function mutations in KIT or PDGFRA, and biological therapies targeted to these receptor tyrosine kinases comprise part of the treatment regimen for metastatic and inoperable GISTs. A minority (10-15%) of GISTs in adults, along with ∼85% of pediatric GISTs, lacks oncogenic mutations in KIT and PDGFRA. Not surprisingly these wild type (WT) GISTs respond poorly to kinase inhibitor therapy. A subset of WT GIST ...[more]