Ontology highlight
ABSTRACT:
SUBMITTER: Killian JK
PROVIDER: S-EPMC4135374 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Killian J Keith JK Kim Su Young SY Miettinen Markku M Smith Carly C Merino Maria M Tsokos Maria M Quezado Martha M Smith William I WI Jahromi Mona S MS Xekouki Paraskevi P Szarek Eva E Walker Robert L RL Lasota Jerzy J Raffeld Mark M Klotzle Brandy B Wang Zengfeng Z Jones Laura L Zhu Yuelin Y Wang Yonghong Y Waterfall Joshua J JJ O'Sullivan Maureen J MJ Bibikova Marina M Pacak Karel K Stratakis Constantine C Janeway Katherine A KA Schiffman Joshua D JD Fan Jian-Bing JB Helman Lee L Meltzer Paul S PS
Cancer discovery 20130402 6
Gastrointestinal stromal tumors (GIST) harbor driver mutations of signal transduction kinases such as KIT, or, alternatively, manifest loss-of-function defects in the mitochondrial succinate dehydrogenase (SDH) complex, a component of the Krebs cycle and electron transport chain. We have uncovered a striking divergence between the DNA methylation profiles of SDH-deficient GIST (n = 24) versus KIT tyrosine kinase pathway-mutated GIST (n = 39). Infinium 450K methylation array analysis of formalin- ...[more]