Landscape of somatic retrotransposition in human cancers.
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ABSTRACT:
SUBMITTER: Lee E
PROVIDER: S-EPMC3656569 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Landscape of somatic retrotransposition in human cancers.
Lee Eunjung E Iskow Rebecca R Yang Lixing L Gokcumen Omer O Haseley Psalm P Luquette Lovelace J LJ Lohr Jens G JG Harris Christopher C CC Ding Li L Wilson Richard K RK Wheeler David A DA Gibbs Richard A RA Kucherlapati Raju R Lee Charles C Kharchenko Peter V PV Park Peter J PJ
Science (New York, N.Y.) 20120628 6097
Transposable elements (TEs) are abundant in the human genome, and some are capable of generating new insertions through RNA intermediates. In cancer, the disruption of cellular mechanisms that normally suppress TE activity may facilitate mutagenic retrotranspositions. We performed single-nucleotide resolution analysis of TE insertions in 43 high-coverage whole-genome sequencing data sets from five cancer types. We identified 194 high-confidence somatic TE insertions, as well as thousands of poly ...[more]
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