Ontology highlight
ABSTRACT:
SUBMITTER: Choe CP
PROVIDER: S-EPMC3656592 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Choe Chong Pyo CP Collazo Andres A Trinh Le A le A Pan Luyuan L Moens Cecilia B CB Crump J Gage JG
Developmental cell 20130131 3
The pharyngeal pouches, which form by budding of the foregut endoderm, are essential for segmentation of the vertebrate face. To date, the cellular mechanism and segmental nature of such budding have remained elusive. Here, we find that Wnt11r and Wnt4a from the head mesoderm and ectoderm, respectively, play distinct roles in the segmental formation of pouches in zebrafish. Time-lapse microscopy, combined with mutant and tissue-specific transgenic experiments, reveal requirements of Wnt signalin ...[more]