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Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents.

ABSTRACT: A combination of MACOS scale-out and ROMP-derived oligomeric triazole phosphates (OTP(n)) have been successfully utilized for the preparation of a 106-member library of triazole containing benzothiaoxazepine-1,1-dioxides. This report demonstrates the utilization of a suite of soluble OTP(n) reagents for facile (triazolyl)methylation of 10 MACOS-derived sultam scaffolds in purification-free process for parallel synthesis of small molecule collections for HTS.

SUBMITTER: Faisal S

PROVIDER: S-EPMC3656824 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents.

Faisal Saqib S Ullah Farman F Maity Pradip K PK Rolfe Alan A Samarakoon Thiwanka B TB Porubsky Patrick P Neuenswander Benjamin B Lushington Gerald H GH Basha Fatima Z FZ Organ Michael G MG Hanson Paul R PR

ACS combinatorial science 20120305 4

A combination of MACOS scale-out and ROMP-derived oligomeric triazole phosphates (OTP(n)) have been successfully utilized for the preparation of a 106-member library of triazole containing benzothiaoxazepine-1,1-dioxides. This report demonstrates the utilization of a suite of soluble OTP(n) reagents for facile (triazolyl)methylation of 10 MACOS-derived sultam scaffolds in purification-free process for parallel synthesis of small molecule collections for HTS. ...[more]

PMID: 22384820

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