Ontology highlight
ABSTRACT:
SUBMITTER: Reixach N
PROVIDER: S-EPMC365703 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Reixach Natàlia N Deechongkit Songpon S Jiang Xin X Kelly Jeffery W JW Buxbaum Joel N JN
Proceedings of the National Academy of Sciences of the United States of America 20040223 9
The transthyretin (TTR) amyloidoses are human diseases in which the misfolded TTR protein aggregates in tissues with subsequent visceral, peripheral, and autonomic nerve dysfunction. Recent reports have stressed the importance of oligomeric intermediates as major cytotoxic species in various forms of amyloidogenesis. We have examined the cytotoxic effects of several quaternary structural states of wild-type and variant TTR proteins on cells of neural lineage. TTR amyloid fibrils and soluble aggr ...[more]