The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.
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ABSTRACT:
SUBMITTER: Matsuoka TA
PROVIDER: S-EPMC365722 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Publications
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.
Matsuoka Taka-aki TA Artner Isabella I Henderson Eva E Means Anna A Sander Maike M Stein Roland R
Proceedings of the National Academy of Sciences of the United States of America 20040218 9
Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. Here, we show that MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cel ...[more]
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