Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury.

ABSTRACT:

Objectives

To test the hypothesis that preconditioning animals with amifostine improves ventilator-induced lung injury via induction of antioxidant defense enzymes. Mechanical ventilation at high tidal volume induces reactive oxygen species production and oxidative stress in the lung, which plays a major role in the pathogenesis of ventilator-induced lung injury. Amifostine attenuates oxidative stress and improves lipopolysaccharide-induced lung injury by acting as a direct scavenger of reactive oxygen and nitrogen species. This study tested effects of chronic amifostine administration on parameters of oxidative stress, lung barrier function, and inflammation associated with ventilator-induced lung injury.

Design

Randomized and controlled laboratory investigation in mice and

SUBMITTER: Fu P 

PROVIDER: S-EPMC3657468 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature