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Necl-4/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination.


ABSTRACT: The timing and progression of axonal myelination are precisely controlled by intercellular interactions between neurons and glia in development. Previous in vitro studies demonstrated that Nectin like 4 (Necl-4, also known as cell adhesion molecule Cadm-4 or SynCAM-4) plays an essential role in axonal myelination by Schwann cells in the peripheral nervous system (PNS). However, the role of Necl-4 protein in axonal myelination in the developing central nervous system (CNS) has remained unknown. In this study, we discovered upregulation of Necl-4 expression in mature oligodendrocytes at perinatal stages when axons undergo active myelination. We generated Necl4 gene knockout mice, but found that disruption of Necl-4 gene did not affect oligodendrocyte differentiation and myelin formation in the CNS. Surprisingly, disruption of Necl-4 had no significant effect on axonal myelination in the PNS either. Therefore, our results demonstrated that Necl-4 is dispensable for axonal myelination in the developing nervous system.

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC3659047 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Necl-4/SynCAM-4 is expressed in myelinating oligodendrocytes but not required for axonal myelination.

Zhu Ying Y   Li Hong H   Li Kehan K   Zhao Xiaofeng X   An Tai T   Hu Xuemei X   Park Jinsil J   Huang Hao H   Bin Yin Y   Qiang Boqin B   Yuan Jiangang J   Peng Xiaozhong X   Qiu Mengsheng M  

PloS one 20130520 5


The timing and progression of axonal myelination are precisely controlled by intercellular interactions between neurons and glia in development. Previous in vitro studies demonstrated that Nectin like 4 (Necl-4, also known as cell adhesion molecule Cadm-4 or SynCAM-4) plays an essential role in axonal myelination by Schwann cells in the peripheral nervous system (PNS). However, the role of Necl-4 protein in axonal myelination in the developing central nervous system (CNS) has remained unknown. I  ...[more]

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