Ontology highlight
ABSTRACT:
SUBMITTER: Howng SY
PROVIDER: S-EPMC2811831 | biostudies-other | 2010 Feb
REPOSITORIES: biostudies-other
Howng Shen Yi B SY Avila Robin L RL Emery Ben B Traka Maria M Lin Wensheng W Watkins Trent T Cook Susan S Bronson Roderick R Davisson Muriel M Barres Ben A BA Popko Brian B
Genes & development 20100115 3
The controlling factors that prompt mature oligodendrocytes to myelinate axons are largely undetermined. In this study, we used a forward genetics approach to identify a mutant mouse strain characterized by the absence of CNS myelin despite the presence of abundant numbers of late-stage, process-extending oligodendrocytes. Through linkage mapping and complementation testing, we identified the mutation as a single nucleotide insertion in the gene encoding zinc finger protein 191 (Zfp191), which i ...[more]