Ontology highlight
ABSTRACT:
SUBMITTER: Rong YP
PROVIDER: S-EPMC3660092 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20080701 2
The antiapoptotic protein Bcl-2 inhibits Ca2+ release from the endoplasmic reticulum (ER). One proposed mechanism involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channel localized with Bcl-2 on the ER. Here we document Bcl-2-IP3R interaction within cells by FRET and identify a Bcl-2 interacting region in the regulatory and coupling domain of the IP3R. A peptide based on this IP3R sequence displaced Bcl-2 from the IP3R and reversed Bcl-2-mediated inhibi ...[more]