Ontology highlight
ABSTRACT:
SUBMITTER: Mataragka S
PROVIDER: S-EPMC6127726 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Mataragka Stefania S Taylor Colin W CW
Journal of cell science 20180823 16
All three subtypes of inositol 1,4,5-trisphosphate receptor (IP<sub>3</sub>R) are intracellular Ca<sup>2+</sup> channels that are co-regulated by IP<sub>3</sub> and Ca<sup>2+</sup> This allows IP<sub>3</sub>Rs to evoke regenerative Ca<sup>2+</sup> signals, the smallest of which are Ca<sup>2+</sup> puffs that reflect the coordinated opening of a few clustered IP<sub>3</sub>Rs. We use total internal reflection microscopy (TIRF) microscopy to record Ca<sup>2+</sup> signals in HEK cells expressing a ...[more]