Ontology highlight
ABSTRACT:
SUBMITTER: Eißmann M
PROVIDER: S-EPMC3661464 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Eißmann Moritz M Schwamb Bettina B Melzer Inga Maria IM Moser Julia J Siele Dagmar D Köhl Ulrike U Rieker Ralf Joachim RJ Wachter David Lukas DL Agaimy Abbas A Herpel Esther E Baumgarten Peter P Mittelbronn Michel M Rakel Stefanie S Kögel Donat D Böhm Stefanie S Gutschner Tony T Diederichs Sven S Zörnig Martin M
PloS one 20130522 5
Yeast cells can be killed upon expression of pro-apoptotic mammalian proteins. We have established a functional yeast survival screen that was used to isolate novel human anti-apoptotic genes overexpressed in treatment-resistant tumors. The screening of three different cDNA libraries prepared from metastatic melanoma, glioblastomas and leukemic blasts allowed for the identification of many yeast cell death-repressing cDNAs, including 28% of genes that are already known to inhibit apoptosis, 35% ...[more]